Severin Lechner

The paper identifies CEM198 as a TTL binder through chemoproteomics, showing it disrupts microtubule dynamics via dual mechanisms in different cell lines.

This paper introduces TRIPs, neomorphic molecules that recruit BAF complexes to rewire BCL6 in DLBCL, inducing apoptosis through chromatin remodeling.

The paper identifies V-ATPase inhibition as a trigger for apoptosis via GCN1/GCN2 kinase signaling and MCL-1 depletion, revealing a therapeutic target in certain cancers.

The paper identifies inhibitor-induced kinase destabilization as a common phenomenon and reveals that it occurs through endogenous proteolytic mechanisms rather than classical ubiquitination.

The paper evaluates the druggability of LC3/GABARAP for autophagy modulators and identifies ligands that bind to the HP2 pocket of the LIR docking site.

The paper provides a comprehensive proteomic map of 13 human brain regions using high-throughput mass spectrometry, highlighting region-specific protein expression patterns and markers.