Author

Xinjia Ruan

China Pharmaceutical UniversityORCID 0000-0003-2309-2641Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Xiaoping SuiD· 2 shared Anna MalovannayaiD· 1 shared Antrix JainiD· 1 shared Branko CuglievaniD· 1 shared Christine E. Birdwell· 1 shared Christopher Peter MilliD· 1 shared Courtney Denton DinardoiD· 1 shared Danielle E. HammondiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Xiaoping SuORCID

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3 papers

Recent·Most cited

ImmunologyBasic Research in CardiologyPeer-reviewedMay 7, 2025

The cGAS-STING Pathway Is Essential in Acute Ischemia-Induced Neutropoiesis and Neutrophil Priming in the Bone Marrow

Jiankun Zhu, Xinjia Ruan, MariaSanta C. Mangione…·Dian J. Cao

This study shows that the cGAS-STING pathway is essential for neutrophil production and function in the bone marrow during acute myocardial ischemia, promoting myocardial repair.

13 citationstop 5%

mousebulk RNA-seq

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Cancer BiologyBloodPeer-reviewedMar 4, 2024

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

Warren C. Fiskus, Jessica C. Piel, Michael P. Collins…·Kapil N. Bhalla

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

49 citationstop 2%

humanbulk RNA-seq

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BioinformaticsThe Innovation MedicinePeer-reviewedJan 1, 2023

DNA replication stress stratifies prognosis and enables exploitable therapeutic vulnerabilities of HBV-associated hepatocellular carcinoma: an in silico strategy towards precision oncology

Xiaofan Lu, Jialin Meng, Haitao Wang…·Fangrong Yan

The paper develops a DNA replication stress-related prognostic index for HBV-associated HCC using machine learning, identifying therapeutic targets and agents for high-risk patients.

5 citations

humanbulk RNA-seq

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