Georgij P. Arapidi

This paper identifies an enhancer lncRNA that interacts with the Androgen Receptor to regulate gene expression and inhibit prostate cancer cell proliferation.

The paper investigates target-mediated miRNA degradation (TDMD) in Drosophila ovarian cells, showing that Dora, the Drosophila ortholog of ZSWIM8, mediates miRNA degradation and affects Notch signaling.

The paper identifies TP63 and TRIM29 as regulators of enhancer methylation and chromosomal instability in prostate cancer by integrating multi-omics data from The Cancer Genome Atlas.

This study shows splicing inhibitors induce DNA repair gene downregulation in cancer cells, creating a vulnerability that can be exploited by combining them with DNA-damaging agents.