Lars A. Carlson

Cryo-ET of Langat virus-infected cells shows replication organelle size set by a membrane coat plus RNA pressure, with virion budding and maturation occurring beside the organelles.

This study identifies ACBD3 as a host factor recruited by flavivirus NS4B to modify ER-Golgi trafficking for virion release.

This paper characterizes Giardia intestinalis deoxyadenosine kinase, showing it forms a tetramer with high substrate affinity and sensitivity to deoxyadenosine analogues, making it a potential drug target.

This study determines the cryo-EM structures of ATG2A and ATG2A-ATG9A complexes, revealing their roles in lipid transfer during autophagosome formation.

This study reconstitutes the membrane clustering and RNA recruitment functions of the enteroviral 2C protein in vitro, revealing its roles in viral replication and challenging its helicase function.

This study inhibits the IST1-CHMP1B interaction in ESCRT-III, impairing endosomal recycling and inducing unconventional LC3 lipidation at stalled endosomes.