Nadine Sommer

This study evaluates AAV-mediated delivery of leptin and adiponectin in a mouse model of congenital generalized lipodystrophy, finding that leptin improves metabolic health while adiponectin does not.

This paper evaluates tissue-selective AAV gene therapy for lipodystrophy in mice, finding that adipose-targeted vectors improve metabolic health without liver expression.

This study shows that liraglutide, a GLP-1R agonist, improves metabolic disease in seipin knockout mice, a model of lipodystrophy, by enhancing insulin secretion and reducing liver fibrosis.