Bryan Heit

The paper shows that MERTK and ADAM17 are localized to distinct membrane microdomains, and MERTK cleavage by ADAM17 occurs only after reorganization of the actin cytoskeleton to bring them together.

This study identifies a MERTK-integrin signaling pathway that coordinates efferocytosis by regulating integrin localization and activation.

This study identifies GATA2 as a key transcription factor driving macrophage proliferation in atherosclerosis by upregulating MYB and reducing apoptosis sensitivity.

The paper investigates phagocytic capacities of B cell subsets and their ability to present antigens to T cells, finding that only peritoneal cavity B1 cells can uptake non-cognate antigens but fail to activate T cells.

This study shows that GATA2 upregulation in macrophages promotes atherogenesis by inducing a stem cell-like transcriptional program that impairs cholesterol efflux and phagocytosis.