Sarah A. Signor

PeakLocus assigns RNA features to transcript intervals with high accuracy, outperforming existing tools in benchmark tests across multiple species.

The paper identifies population-specific alternative polyadenylation (APA) responses to acute ethanol exposure in Drosophila melanogaster, showing genotype- and population-dependent shifts in 3' UTR length.

The paper analyzes piRNA cluster evolution in D. simulans using genome and piRNA data, finding rapid formation and loss of clusters and distinct transposon involvement compared to D. melanogaster.

The paper identifies 648 recent transposable element horizontal transfers in Drosophila using 400 dipteran genomes, revealing patterns of transfer frequency and phylogenetic distance.

The paper identifies and traces the spread of the endogenous retrovirus Kuruka in Drosophila melanogaster populations, showing its recent horizontal transfer from an Afrotropical species.

This study uses simulations to show that transposable element insertion bias into piRNA clusters can alter invasion dynamics but is generally not beneficial for TE spread, with limited scenarios where it might be advantageous.

This study tracks polygenic adaptation in Drosophila populations under a new diet, showing a directional phase followed by a stabilizing phase with phenotypic stasis.

The paper identifies three recent horizontal transposon element transfers in D. melanogaster and links them to human activities.

The paper identifies Spoink, a LTR retrotransposon that invaded D. melanogaster populations between 1983 and 1993, likely via horizontal transfer from D. willistoni, and shows it is often silenced by the piRNA pathway.

This paper introduces TranD, a tool for comparing transcriptome structures using nucleotide-level distance metrics to assess transcript complexity and structural differences between species or annotations.

The paper characterizes transposable element variation in Drosophila serrata and finds evidence of host-transposable element interactions and burst dynamics in inbred lines.

The paper quantitatively analyzes spatial gene expression in Drosophila eye development across species, genotypes, and sexes, revealing genetic stochasticity and evolutionary changes in gene regulatory relationships.