James H. Crichton

The paper introduces computational tools for automated quantitative analysis of meiotic prophase I images, focusing on chromosome axis and recombination focus measurements.

This study shows Tex19.1 maintains acetylated SMC3 and sister chromatid cohesion in mouse oocytes, preventing aneuploidy.

The paper shows that a recombination-dependent checkpoint in mouse spermatocytes delays pachytene progression to accommodate recombination defects.

This study identifies Tex19.1 and Ubr2 as regulators of meiotic DNA double strand break frequency in mouse spermatocytes, ensuring proper homologous chromosome pairing and meiotic progression.