A. Arockia Jeyaprakash

The paper identifies SPOUT1/CENP-32 as a causative gene for SpADMiSS, linking its dysfunction to mitotic spindle defects and neurodevelopmental disorders.

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.

The paper shows that DHRS7 loss increases nuclear size in prostate cancer cells and that estradiol propionate reduces nuclear size in DHRS7-lacking cells, suggesting DHRS7 as a biomarker for estrogen therapy effectiveness.

The paper identifies a conserved arginine residue in the Dam1 complex subunit Dad2 that is essential for viability in yeast but less so in fungi with regional centromeres, suggesting functional plasticity in chromosome-microtubule coupling.

The paper identifies the SPARC complex in Trypanosoma brucei, showing it defines RNAPII promoters and regulates transcription start site positioning and directionality.

The paper identifies chromatin factors in Trypanosoma brucei and their association with transcription initiation and termination sites through proteomic and ChIP-seq analyses.

This study tracks DNA rearrangements during HAC formation and finds that early stages involve DNA shredding and shuffling similar to chromothripsis.

This study uses a heterologous system to investigate how dCENP-A is propagated in human cells, identifying key interactions between dCENP-C, CAL1, and dCENP-A for epigenetic centromere inheritance.