Gaurav Chauhan

The paper designs synthetic scaffold proteins that form cell-cell interfaces with switch-like condensation behaviors, enabling selective and specific intercellular interactions.

This study uses simulations to show that scaffold protein phase separation influences receptor clustering and synaptic bistability by altering inter-receptor interactions.

This paper maps the critical regime of an intrinsically disordered protein using simulations and finite-size scaling, identifying three distinct phase behavior regimes.

This paper demonstrates a polymerization-free hydrogel fabrication method using spontaneous phase separation, enabling encapsulation of live cells, antibiotics, and plant seeds.

This study uses simulations to show how varying stiffness in polymers affects their collapse and adsorption in crowded environments, with flexible regions promoting collapse and semiflexible regions influencing adsorption.

The paper investigates anisotropies in RNA-based biomolecular condensate interfaces, finding that purine-rich RNAs drive phase separation while pyrimidine-rich RNAs accumulate at interfaces, with distinct motion patterns observed using single-molecule imaging.

The paper shows that glutamate reveals distinct energy and length scales for phase separation and clustering of FET family proteins in sub-saturated solutions.

This paper demonstrates that macromolecular crowding and confinement in cell-free systems can spatially organize transcription and translation, mimicking prokaryotic nucleoid behavior.