Hannes Ausserwöger

This study shows that biomolecular condensates can sustain pH gradients without energy input by neutralizing charges, revealing their role in creating pH microenvironments.

This paper investigates the molecular mechanisms of opalescence and liquid-liquid phase separation in mAb formulations and shows they are decoupled from aggregation.

This paper introduces a dominance analysis framework to determine the molecular mechanism of condensate modulation, demonstrating its application to G3BP1/RNA condensates disrupted by suramin.

The paper investigates anisotropies in RNA-based biomolecular condensate interfaces, finding that purine-rich RNAs drive phase separation while pyrimidine-rich RNAs accumulate at interfaces, with distinct motion patterns observed using single-molecule imaging.

This study identifies sequence-encoded molecular grammars in synapsin-1 IDRs that drive condensation and generate pH gradients relevant for synaptic function.

The paper investigates how temperature affects G3BP1-RNA phase separation, revealing that while the phase boundary remains stable, stoichiometry and energetics shift, driven by entropic processes.