Nesli E. Sen

The paper identifies atonosomes as tension-responsive plasma membrane-derived compartments in yeast, showing they form rapidly in response to membrane tension loss and are regulated by cell wall dynamics.

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

This study determines the cryo-EM structure of native yeast eisosomes, revealing lipid organization and dynamic stretching mechanisms in membrane microdomains.