Wolfgang Lieb

This study shows that PPI-associated microbiome changes cause systemic metabolic and transcriptional responses, affecting metabolism and inflammation in multiple tissues.

The paper uses genome-scale metabolic models to predict how diet and lifestyle affect microbial interactions in the gut microbiome, finding shifts from collaboration to competition with high sugar intake.

The paper develops an improved polygenic score for idiopathic Parkinson's disease, showing higher discriminative performance and explaining variable penetrance in genetic forms of the disease.

The paper introduces a method to compress genetic data using autoencoders that leverage linkage disequilibrium structure, achieving high reconstruction accuracy while reducing data size.

The paper uses scRNA-seq to identify aberrant differentiation in nasal epithelium of PCS patients, linking immune cell presence and inflammatory signaling to persistent symptoms.

This study performs a genome-wide association analysis of hemorrhoidal disease in 944,133 individuals, identifying 102 risk loci and linking them to vascular and tissue development pathways.

This study identifies 13 new genetic loci specific to proximal or distal colorectal cancer subtypes, revealing partly distinct genetic architectures for these tumor locations.

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.

This study identifies shared genetic loci between multiple system atrophy and inflammatory bowel disease using conjFDR, highlighting immune and gut-related molecular mechanisms.