Κωνσταντίνος Κωνσταντόπουλος

This study enhances CAR-T cell migration through synthetic cytokine receptors, reducing metastasis in TNBC mouse models.

The paper shows that cancer cells switch between glycolysis and oxidative phosphorylation based on microenvironment stiffness, affecting their migration patterns.

This study shows that increasing fluid viscosity can temporarily restore young-like surveillance behaviors in aged human T cells by improving deformability and sensing.

This study shows that non-excitable cells have spatially varying membrane potentials linked to anionic lipid distribution and mechanical factors, challenging the traditional view of membrane potential regulation.

This study identifies a chemical compensation mechanism in cells responding to mechanical stimuli, revealing non-monotonic changes in volume and pH mediated by PI3K/Akt and MAPK/ERK pathway interactions.

This study investigates how cancer cells dissociate from an invading front, finding that single-cell rupture is most common and influenced by adhesion and chemotaxis.

This study shows that Ras activity has a biphasic effect on cell migration, with both high and low activity impairing movement, and reveals that Ras regulates migration through rapid, non-transcriptional mechanisms.

This study identifies a mechanism where cytoskeletal activation of NHE1 drives secondary volume increase and affects cell proliferation in response to hypotonic stress.