Author

James T. O’Connor

Vanderbilt UniversityORCID 0000-0003-2642-1594Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. Joseph BloomiD· 1 shared Aaron D. GitleriD· 1 shared Aaron DiAntonioiD· 1 shared Andrea W. PageiD· 1 shared Caiwei GuoiD· 1 shared Dennis W. DicksoniD· 1 shared Hui Qi Loo· 1 shared Ivy S. Han· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

A. Joseph BloomORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintNov 21, 2025

TDP-43 suppression of ATP8A2 cryptic splicing implicates phosphatidylserine-driven neuroinflammation in ALS/FTD

James T. O’Connor, Hui Qi Loo, Caiwei Guo…·Aaron DiAntonio

This study identifies ATP8A2 as a TDP-43 target whose loss leads to PS exposure and neuroinflammation, suggesting immune cell inhibition as a therapeutic strategy for ALS-FTD and CAMRQ4.

2 citations

mousehuman

𝕏 PostBluesky

BiophysicsMolecular Biology of the CellPeer-reviewedMar 27, 2024

After wounding, a G-protein coupled receptor promotes the restoration of tension in epithelial cells

Ivy S. Han, Junmin Hua, James S. White…·M. Shane Hutson

This study shows that the GPCR Mthl10 and IP3 receptor are required for restoring cellular tension after wounding in Drosophila epithelial cells.

10 citations

Drosophilaimaging

𝕏 PostBluesky