Christophe Gonçalves

The paper identifies atypical B cells (ABCs) as mediators of poor response to BCG immunotherapy in high-risk NMIBC patients, linking their expansion and FCRL5 expression to early recurrence.

This study identifies RAB1A as a vulnerability in uveal melanoma through dual inhibition of MNK1/2 and mTOR, showing it disrupts protein trafficking and blocks liver metastasis.

This study identifies the CCL17-CCR4 axis as a driver of therapeutic resistance in STAT6D419 mutant rrDLBCL by promoting T cell infiltration and microenvironmental changes.

This study uses PhenoCycler imaging to analyze the tumor microenvironment in murine cancer models, revealing distinct TME features and cell-cell contact differences across cancer types.