Koren Kathleen Mann

This study identifies the CCL17-CCR4 axis as a driver of therapeutic resistance in STAT6D419 mutant rrDLBCL by promoting T cell infiltration and microenvironmental changes.

This study shows that moderate-dose arsenical exposure during mouse kidney development impairs nephron formation and increases the risk of chronic kidney disease.

This study uses single-cell multi-omics profiling to show arsenic alters macrophage transcription and epigenetics in atherosclerotic plaques, with more profound epigenetic changes.

scCross integrates and generates single-cell multi-omics data using deep generative models, enabling seamless cross-modal analysis and in-silico experiments.

This study uses PhenoCycler imaging to analyze the tumor microenvironment in murine cancer models, revealing distinct TME features and cell-cell contact differences across cancer types.