Nicolas H. Thomä

The paper identifies CRBN-pomalidomide binders using a combination of GluePCA and AI-derived protein surface queries, revealing known and novel interactors for MGD development.

This study shows that SERDs induce ER SUMOylation, which recruits co-repressors to suppress transcription, rather than relying on ER degradation for their activity.

This study identifies PP2A-A as a target of CRL3KBTBD4, showing that KBTBD4 mutations disrupt PP2A quality control and contribute to medulloblastoma by altering phospho-dependent signaling.

The paper shows E2F1 induces cell-cycle reentry without changing chromatin accessibility by using pre-existing regulatory elements.

The paper shows that tandem E-boxes enable CLOCK:BMAL1 to bind more sites on nucleosomes, promoting multivalent interactions with CBP/p300 to drive gene expression.

The paper shows BMAL1-HIF2α heterodimers contribute to ccRCC growth and drug sensitivity by regulating HIF2 target genes and chromatin association.

The paper uses cryo-EM to study the E6AP-E6-p53 complex, revealing new interaction interfaces and stoichiometry.

This study shows that Trim24 restricts p53's ability to open chromatin by binding to closed chromatin regions and interacting with unmethylated histone H3 lysine 4.

This study identifies RIF1 as a phosphopeptide-binding protein that interacts with phosphorylated 53BP1 epitopes to facilitate DNA repair and modulate shieldin recruitment.