Georg Kempf

The paper identifies CRBN-pomalidomide binders using a combination of GluePCA and AI-derived protein surface queries, revealing known and novel interactors for MGD development.

This study shows that SERDs induce ER SUMOylation, which recruits co-repressors to suppress transcription, rather than relying on ER degradation for their activity.

The paper shows that tandem E-boxes enable CLOCK:BMAL1 to bind more sites on nucleosomes, promoting multivalent interactions with CBP/p300 to drive gene expression.

The paper systematically mutagenizes human bZIP domains and uses deep mutational scanning to quantify interactions, revealing complex genetic architecture and enabling synthetic bZIP design.

The paper develops qPISA to quantify protease substrate turnover, revealing subsite cooperativity in DPP4 and distinguishing it from DPF-3.

The paper quantifies how mutations in JUN affect its binding to 54 human basic leucine zipper transcription factors, revealing that specificity is encoded by both positive and negative determinants.

This study identifies ChAHP2, a protein complex that controls ERVs and LINEs by binding H3K9me3, and shows that ChAHP and ChAHP2 work together to repress retrotransposons.

The paper uses cryo-EM to study the E6AP-E6-p53 complex, revealing new interaction interfaces and stoichiometry.

GUIFold provides a user-friendly interface for AlphaFold2, enabling job tracking, submission, and prediction evaluation without technical expertise.