Yahaira Naaldijk

This study identifies LRRK2's role in impairing dopamine axon release sites in Parkinson's disease, leading to reduced dopamine release and synaptic dysfunction.

This study shows that pathogenic LRRK2 mutations cause age-dependent and region-specific deficits in ciliation, innervation, and viability of cholinergic neurons in mice.

This paper demonstrates that constrained peptides mimicking phosphorylated Rab8 can block RILPL interactions and restore ciliogenesis and centrosomal cohesion defects in cells with mutant LRRK2.

Peripheral blood-derived cells can be employed to stratify Parkinson's disease patients most likely to respond to LRRK2-related therapeutics.

This study shows that LRRK2 kinase activity causes centrosomal cohesion deficits through phosphorylated Rab10 and RILPL1 at centriolar subdistal appendages.