Paul D. Upton

This paper investigates the glycolytic axis in PAH models and shows that TEPP-46 treatment reduces nuclear PKM2 and improves PAH symptoms in rodent models.

This study shows that interleukin-6 is critical in gcn2-mutation associated pulmonary vascular disease in mice, as its deletion rescues pulmonary hypertension phenotypes.

This study identifies ATP13A3 as a polyamine transporter whose deficiency leads to endothelial dysfunction and pulmonary arterial hypertension.

This study identifies novel rare genetic variants associated with heritable pulmonary arterial hypertension through whole genome sequencing of cases and controls.