Chih Hung Lo

The paper compares proteomic profiles of extracellular vesicles from different human neural cell types to identify cell-type-specific cargo and functional roles.

This study evaluates a peptide-based inhibitor of TNFR1 signaling in a human TNF transgenic mouse model of RA, showing reduced inflammation and improved disease outcomes.

This study shows lysosome-acidifying nanoparticles rescue neuronal death in A30P α-synuclein models by restoring lysosomal function and autophagy.

This study develops TFSA nanoparticles that restore lysosomal acidification and improve metabolic function in pancreatic β-cells under lipotoxic conditions.

This study shows defective lysosomal acidification contributes to TNFR1-mediated neuronal necroptosis in Alzheimer's disease and demonstrates that lysosome-acidifying nanoparticles can rescue this process.

The paper identifies potent small molecules that inhibit toxic alpha-synuclein oligomers and reduce cell death in SH-SY5Y cells using a FRET-based biosensor platform.

The paper develops a FRET-based biosensor platform to screen small molecules targeting toxic tau oligomers, identifying MK-886 as a compound that disrupts tau oligomers and reduces cytotoxicity.