Lech Kaczmarczyk

This study identifies fast-conducting mechano-nociceptors as essential for mechanical nocifensive behaviors and sensitization in mice and humans.

This study shows that vaccination reduces prion shedding in feces and urine of CWD-infected mice, potentially breaking the transmission cycle.

The paper introduces a new mouse line expressing FlpO recombinase specifically in NaV1.8-expressing sensory neurons, enabling selective intersectional targeting of C-fiber mechanoreceptors and nociceptors.

This paper introduces a new NefhCreERT2 knock-in mouse line for selectively targeting myelinated primary afferent neurons, enabling genetic studies of these fibers while excluding unmyelinated C fibers.

The paper identifies Rps24c/S24-PKE as a novel marker for neuroinflammation and neurodegeneration through cell type-specific alternative splicing in mouse brains.

The paper identifies a fast nociceptive pathway that mediates rapid reflexive behavior but not affective pain.

The paper compares the interactomes of mouse and bank vole prion proteins in brain tissue to determine if differences in protein interactions explain the bank vole's susceptibility to prions.

This study tests anti-prion drugs on knock-in mouse models of inherited prion diseases and finds they do not improve survival or prevent prion accumulation.

The paper shows DNA G-quadruplex regulates gene expression in neurons, affecting memory formation and fear extinction.

This study shows that knock-in mice with specific prion protein mutations spontaneously develop prion disease, producing atypical prion strains with similar properties regardless of mutation type.

The paper identifies cell type-specific transcriptomic changes in cerebellar neurons of a Huntington's disease mouse model, highlighting cyclin D1 upregulation in granule cells.

The paper identifies early translatome changes in specific neural cell types before EEG and neuropathological signs of prion disease in mice.

The paper compares behavioral traits between C57Bl/6 and 129S4 mice, establishes a new Cre mouse line for astrocyte study, and investigates calcium signaling and gene expression in astrocytes.