Aymeric Silvin

This study develops a syngeneic mouse model of MSI cancer and shows that immune responses regulate metastasis in MSI-H tumors, with specific immune cell infiltration observed in metastatic sites.

This study identifies circulating senescent myeloid cells as drivers of blood-brain barrier breakdown and neurodegeneration in LCH-ND.

This study shows that Ermin deficiency causes myelin abnormalities and inflammation, leading to neurological deficits and increased susceptibility to demyelination, suggesting it as an 'inside-out' model for inflammatory dysmyelination.