BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicry
Natalie H. Jones, Qiwen Liu, Linas Urnavicius…·Tarun M. Kapoor
This paper identifies VA1, a small molecule that activates VCP/p97, and reveals its allosteric mechanism through cryo-EM structures and mutagenesis studies.
11 citations