Tarun M. Kapoor

This study shows that VPS4 and CHMP7 are required for releasing centromeres from the nuclear envelope after mitosis, preventing DNA damage and ensuring proper positioning.

This paper reports cryo-EM structures of NEDD1 bound to the human γ-TuRC with and without CDK5RAP2, revealing how NEDD1 anchors the complex and orients its microtubule-binding domains.

This study identifies how VCP interacts with DUBs at distinct sites to coordinate ubiquitin removal during protein recycling.

This paper identifies VA1, a small molecule that activates VCP/p97, and reveals its allosteric mechanism through cryo-EM structures and mutagenesis studies.

The paper reports the structure of the γ-tubulin ring complex-capped microtubule, revealing how it nucleates and stabilizes 13-protofilament microtubules.

The paper develops covalent inhibitors for conformationally dynamic helicases using electrophilic scout fragments and a function-first approach, targeting SARS-CoV-2 nsp13 and human helicases BLM and WRN.