Author

Twan Otten

Radboud University Medical Center, Nijmegen, The Netherlands;ORCID 0000-0003-2880-9111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Jan van Lunzen· 2 shared Leo A. B. JoosteniD· 2 shared Linos VandekerckhoveiD· 2 shared Mareva DelporteiD· 2 shared Sarah GerloiD· 2 shared Vasiliki MatzarakiiD· 2 shared Victoria Rios-VazqueziD· 2 shared Adriana NavasiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Jan van Lunzen

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 11, 2026

Biological aging and comorbidities are linked to HIV 1 reservoir size despite suppressive antiretroviral therapy

Mareva Delporte, Twan Otten, Kavita Mehta…·Linos Vandekerckhove

This study links HIV reservoir size to biological aging and non-AIDS comorbidities in people on suppressive antiretroviral therapy, independent of inflammation and immune history.

DOI 10.64898/2026.11.09.765455

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintJul 28, 2026

Multi-Omics Clustering Differentiates the Total and Intact HIV Reservoirs and Related Host Immune Mechanisms

Victoria Rios-Vazquez, Mareva Delporte, Twan Otten…·Linos Vandekerckhove

This study uses multi-omics clustering to identify three immunological endotypes in HIV patients, linking them to distinct HIV reservoir sizes and immune mechanisms.

DOI 10.64898/2026.06.24.734029

humanbulk RNA-seq

𝕏 PostBluesky