Linos Vandekerckhove

This study links HIV reservoir size to biological aging and non-AIDS comorbidities in people on suppressive antiretroviral therapy, independent of inflammation and immune history.

The paper identifies eicosanoid-enriched follicular microenvironments in HIV-infected individuals on antiretroviral therapy that may influence antibody responses and viral reservoir persistence.

This study uses multi-omics clustering to identify three immunological endotypes in HIV patients, linking them to distinct HIV reservoir sizes and immune mechanisms.

This study develops Hybrid CAR-T cells that secrete broadly neutralizing antibodies, showing in vitro HIV elimination and in vivo viral suppression in humanized mice.

This study shows that HIV persistence accelerates immune aging in treated individuals, while certain antiretroviral drugs reduce it.

The paper develops a multiplexed digital PCR assay to quantify total and intact HIV-1 reservoirs, showing it is more specific than existing methods and enables high-throughput analysis.

HIV-PULSE is a long-read sequencing assay that enables high-throughput, accurate characterization of HIV-1 proviral genomes without limiting dilution steps.