Jixing Lyu

This study investigates how Zn2+ activates PaMsbA, an ABC transporter in Pseudomonas aeruginosa, by enhancing its ATPase activity and promoting dimerization.

This study investigates how vertebrate hemoglobin evolved from a homodimeric ancestor to a heterotetramer through simple genetic changes that exploited symmetry in its structure.

The paper uses native mass spectrometry and mutant cycles to study the thermodynamics of MsbA-LPS interactions, revealing entropy-driven binding and conformational changes.