Damien Portevin

The paper compares immune responses to Mycobacterium tuberculosis in African and European donors using CyTOF, finding divergent profiles linked to geographic origin and immune control.

The paper investigates how granulysin from immune cells induces dormancy in Mycobacterium tuberculosis, revealing an immune escape mechanism.

This study examines how different Mycobacterium tuberculosis complex lineages elicit varying granulomatous responses in vitro, linking genetic diversity to immune activation and bacterial growth.

This study examines the relationship between human genetic ancestry, Mycobacterium tuberculosis diversity, and TB disease severity in Dar es Salaam, Tanzania, finding no significant genetic influence on disease severity.

The study infects macrophages from tuberculosis patients with different MTBC lineages to show that bacterial phylogenetic diversity, not local adaptation, drives variable macrophage responses.

The paper improves genotype imputation in underrepresented populations by adding population-specific SNPs to existing reference panels, showing improved accuracy in a Tanzanian cohort.