Wen‐Chien Chou

This paper introduces a deep learning model using multiple instance learning to predict gene mutations from whole slide images of AML without manual annotations, achieving high AUC scores for NPM1 and FLT3-ITD mutations.

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.