Hugo Sepúlveda

The paper shows TET3 and MECP2 interact to regulate neuronal maturation, with TET3 critical for functional development and MECP2 inhibiting TET3 activity.

This study shows that loss of TET function in Treg cells leads to ex-Treg cells that differentiate into Tfh cells, promoting autoantibody production and autoimmune disease.

This study links increased transposable element (TE) expression in SLE patients to IFN responses, showing strong correlations with disease activity and splicing alterations.

This study shows that OGT inhibits TET activity, preventing DNA demethylation and transposable element expression in heterochromatin.

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.