Giovanni Tonon

This paper identifies that cancer persister cells activate NMDARs to survive ferroptosis, and inhibiting both the Xc- antiporter and NMDAR/NFE2L2 axis resensitizes them to ferroptosis.

This paper introduces SCOUT, a synthetic whole-genome sequencing resource for benchmarking cancer genomic analysis, revealing performance issues in complex tumours and highlighting the importance of evolutionary ground truth.

The paper introduces GenomeAnonymizer, a method to anonymize tumor-normal DNA sequences, creating STTs that preserve somatic variants and enable open research while protecting privacy.

This paper develops a bioprinting system for miniaturized hanging-drop organoid cultures in sBME, improving scalability and reproducibility for high-throughput applications.

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

This paper introduces a high-throughput microfluidic platform for organoid culture and multi-omics profiling, demonstrating its utility in clinical and drug discovery settings.

This study shows that disrupting the WRAD core in pancreatic cancer leads to DNA replication errors, immune response activation, and improved response to immune checkpoint inhibitors.

The paper demonstrates the use of dual host-bacterial gene expression analysis in FFPE tissues to study pathogenesis and virulence factor regulation during respiratory infections.

This study shows KDM6A regulates immune response genes in multiple myeloma by activating NLRC5 and CIITA, and its loss reduces MHC expression, which can be reversed by HDAC3 inhibitors.

The paper develops a standardized data model for cancer genomics to enable interoperable data sharing across countries.

This paper introduces a framework for integrating multiomic single-cell data using Wasserstein GANs, enabling analysis of more than two modalities with reduced computational burden.