Patrícia Alves de Castro

This study compares phenotypic, metabolomic, and genomic variation between two Aspergillus species to determine factors distinguishing opportunistic pathogens from non-pathogens.

This study identifies RAB5c's role in regulating non-canonical autophagy machinery to enhance phagosome maturation and microbial killing by macrophages.

This study examines strain variation in a non-pathogenic fungus, identifying factors linked to virulence differences across strains.

The paper shows milteforan, a veterinary product containing miltefosine, is effective against sporotrichosis caused by S. brasiliensis and S. schenckii in vitro and in infected cells.

This study shows that brilacidin enhances ibrexafungerp's antifungal effect against Aspergillus fumigatus, including strains resistant to caspofungin.

This paper identifies brilacidin as a novel antifungal agent effective against Cryptococcus neoformans, showing it reduces fungal survival in macrophages and potentiates existing antifungals.

This study shows that sirtuins in Aspergillus fumigatus are important for virulence and pathogenesis, with AfSirE deletion reducing virulence and altering protein acetylation and gene expression.

The paper compares chromatin activities in two A. fumigatus isolates, finding higher genome instability in Af293 and identifying a variant with chromosomal alterations linked to increased virulence.