Author

Cátia Silveiro

University of LisbonORCID 0000-0003-3052-6372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

David PiresiD· 3 shared Elsa AnesiD· 3 shared Francisco OlivençaiD· 3 shared Maria João CatalãoiD· 3 shared Bianca Ervatti GamaiD· 1 shared Diana MortinhoiD· 1 shared Frederico HoltremaniD· 1 shared Manoj MandaliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

David PiresORCID

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3 papers

Recent·Most cited

MicrobiologyScientific ReportsPeer-reviewedJun 23, 2026

Genetic interference of distinctive Mycobacterium tuberculosis peptidoglycan modifications enhances β-lactam susceptibility and reveals expression-sensitive host immune dynamics

Cátia Silveiro, Mariana Marques, Francisco Olivença…·Maria João Catalão

This study uses CRISPRi to silence Mtb genes involved in peptidoglycan modifications, showing their role in β-lactam resistance and host immune responses.

DOI 10.1038/s41598-026-59172-9

genetic perturbation / CRISPRhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologybioRxivPreprintJul 8, 2025

Effects of CwlM, a peptidoglycan synthesis regulator, on beta-lactam resistance and host-pathogen interactions

Cátia Silveiro, Diana Mortinho, Francisco Olivença…·Maria João Catalão

This study investigates the role of CwlM in beta-lactam resistance and intracellular survival in Mycobacterium smegmatis, finding it promotes resistance and supports survival in macrophages without PG-hydrolytic activity.

1 citation

proteomicsexperimental assay

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MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewedFeb 27, 2024

Ethambutol and Meropenem/Clavulanate Synergy Promotes Enhanced Extracellular and Intracellular Killing of Mycobacterium tuberculosis

Francisco Olivença, David Pires, Cátia Silveiro…·Maria João Catalão

This paper shows that combining ethambutol with beta-lactams like meropenem enhances extracellular and intracellular killing of Mycobacterium tuberculosis through synergistic effects on cell wall synthesis.

14 citations

humanproteomics

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