Eric Malekos

The paper identifies and functionally characterizes noncanonical coding sequences in mouse macrophages, revealing retrovirus-derived proteins as regulators of immune signaling.

The paper identifies INSTAR, a novel lncRNA, as a growth suppressor in human monocytes through a CRISPRi screen, showing it regulates SFMBT2 expression to control proliferation.

The paper shows E2F1 induces cell-cycle reentry without changing chromatin accessibility by using pre-existing regulatory elements.

The paper examines how bacterial diversity affects ecosystem function in pitcher plant communities, finding a negative relationship for broad functions but positive or neutral for narrow ones.

CRISPRware designs context-specific gRNAs using sequencing data, enabling allele-specific targeting across the genome for gene therapy applications.

The paper uses a CRISPRi screen to identify lncRNAs critical for human monocyte viability, finding two lncRNAs that regulate proliferation and cell cycle genes.

The paper identifies and functionally characterizes lncRNAs involved in human monocyte-to-macrophage differentiation using RNA-seq and high-throughput screening.

The paper uses CRISPRi screens to identify the lncRNA LOUP as a regulator of macrophage differentiation and inflammatory signaling through epigenetic and peptide-mediated mechanisms.

This study shows HNRNPA2B1 regulates IFNG signaling in macrophages by controlling IFNG receptor splicing and bacterial restriction.