Susan B Carpenter

This study identifies hnRNPA2B1 as a splicing regulator that modulates anti-mycobacterial immune responses in macrophages by controlling alternative splicing of Irgm1.

The paper identifies and functionally characterizes noncanonical coding sequences in mouse macrophages, revealing retrovirus-derived proteins as regulators of immune signaling.

This study identifies VILMIR as a long noncoding RNA that enhances the host interferon response by interacting with transcriptional and translational regulators in human epithelial cells.

The paper identifies INSTAR, a novel lncRNA, as a growth suppressor in human monocytes through a CRISPRi screen, showing it regulates SFMBT2 expression to control proliferation.

CRISPRware designs context-specific gRNAs using sequencing data, enabling allele-specific targeting across the genome for gene therapy applications.

The paper uses a CRISPRi screen to identify lncRNAs critical for human monocyte viability, finding two lncRNAs that regulate proliferation and cell cycle genes.

This study identifies VILMIR, a novel lncRNA upregulated by respiratory viral infections and IFN-β, which modulates the host interferon response.

EssSubgraph improves essential gene prediction by integrating networks and omics data, showing better performance and cross-species generalizability than existing methods.

The paper identifies and functionally characterizes lncRNAs involved in human monocyte-to-macrophage differentiation using RNA-seq and high-throughput screening.

The paper uses CRISPRi screens to identify the lncRNA LOUP as a regulator of macrophage differentiation and inflammatory signaling through epigenetic and peptide-mediated mechanisms.

This study shows HNRNPA2B1 regulates IFNG signaling in macrophages by controlling IFNG receptor splicing and bacterial restriction.

This study identifies lincRNA-Cox2 as a regulator of smoke-induced inflammation in murine macrophages, showing its role in modulating inflammatory gene expression and splicing.