Tatsuya Tsukui

The paper identifies IAV-driven fibroblast states and shows that loss of TGFβ signaling enhances immuno-modulatory fibroblasts, supporting T2-Tregs to improve lung outcomes.

This study identifies senescent fibroblasts in lung cancer stroma that alter tumor metabolism and plasticity, and shows that targeting these cells with XL888 reduces tumor burden.

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

This study shows that fibroblast proliferation drives pulmonary fibrosis and that targeting this process could be a new therapeutic strategy.

This study identifies β-III tubulin as a marker for anti-fibrotic pericytes in pulmonary fibrosis and shows that Tuj1-expressing pericytes release CXCL10 to inhibit pro-fibrotic macrophage differentiation.

This study identifies impaired myofibroblast proliferation as a central feature of alveolar simplification in BPD using single-cell RNA sequencing and pharmacologic approaches.

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.