Kenny L. Chan

The paper develops a method to study endogenous protein complexes in brain tissue and finds mGluR2/3 heterodimers are abundant in specific human brain regions and associated with depression.

This study identifies astrocyte-derived extracellular matrix proteins, particularly SPARC, as regulators of synapse remodeling in stress-induced depression.

The paper shows acetate supplementation improves social deficits and changes gene expression in the prefrontal cortex of Shank3-deficient mice.

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

The paper shows that social rank and history of winning influence stress susceptibility in mice, with dominance conferring resilience and subordination increasing susceptibility.

This study shows orexin signaling in GABAergic lateral habenula neurons promotes aggression and conditioned place preference, suggesting a potential therapeutic target for reducing aggressive behaviors.