Philippos Demetriou

This study shows that blocking the endothelin receptor pathway enhances T cell and CAR T cell therapies in cancer models by improving antitumour responses and durable immunity.

This study shows CD2 expression is co-regulated with stemness and exhaustion factors in T cells, and identifies SUZ12 and BAP1 as regulators of CD2 expression.

The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.