Ulrich F. Keyser

The paper shows that increasing LiCl concentration beyond 4 mol/L significantly increases translocation time for dsDNA and RNA:DNA hybrids in solid-state nanopores, improving barcode sensing resolution.

This study uses nanopore sensing to profile PEGylation of pegaptanib, revealing PEG heterogeneity and stability in serum.

This paper introduces modular RNA:DNA nanostructures for direct, amplification-free rRNA profiling, enabling detection of rRNA variants and processing states.

This paper introduces a nanopore-based method to directly quantify RNA tandem repeats, achieving 18-nucleotide resolution and successfully detecting disease-associated repeats in DM1, DM2, and CCHS1.

The paper compares the electrophoretic translocation dynamics of RNA:DNA hybrids and DNA:DNA duplexes through nanopores, finding that RNA:DNA hybrids translocate faster despite similar contour lengths.

This paper introduces a method using RNA nanotechnology and nanopores to quantitatively analyze alternative transcription termination at the single-molecule level.

This paper introduces a single-molecule method using solid-state nanopores and DNA barcoding to detect and characterize misfolded protein oligomers, demonstrating its application to α-synuclein in Parkinson's disease.

This study shows that DNA secondary structures like G4s and iMs cause replication fork arrest and breakage, and that Pif1 helicase is required to resolve stalled forks.

This study shows that DNA-based ion channels with continuous backbones form more stable and efficient pores in lipid membranes than those with nicks.

The paper develops a microfluidic platform that purifies and integrates the production of GUVs with their manipulation, achieving high efficiency in separating vesicles from residues.