Claudio Alfieri

The paper introduces synthetic peptides to improve cryo-EM grid preparation for multi-subunit protein complexes by reducing disassembly and preferred orientation.

The paper presents the cryo-EM structure of the CDK11-cyclin L-SAP30BP complex, revealing mechanisms of CDK11 regulation and inhibitor selectivity.

This study identifies a non-centromeric role for CENP-B in binding hairpin motifs in chromosome arms, leading to dysregulated gene expression upon depletion.

This study uses PRISMA to identify and map novel ARID1A interactions at high sequence resolution, revealing new interactors and a regulatory mechanism involving CDK2 phosphorylation.

The paper shows that spatial regulation of the APC/C at mitotic chromosomes enables rapid Cyclin B1 degradation, ensuring proper cell division and genomic stability.

The paper presents the structure of the SIN3B histone deacetylase complex and elucidates its mechanism of substrate recognition and catalysis.