Author

James David Sutherland

CIC bioGUNEORCID 0000-0003-3229-793XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Félix ElortzaiD· 4 shared Mikel AzkargortaiD· 4 shared Ibón IloroiD· 3 shared Rosa BarrioiD· 3 shared Amaia Zabala‐LetonaiD· 2 shared Arkaitz CarracedoiD· 2 shared Coralia PéreziD· 2 shared Ianire AstobizaiD· 2 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

Félix ElortzaORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 2, 2025

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

Laura Bozal‐Basterra, María-Camila Salazar, Ana Margarida Ferreira Campos…·Arkaitz Carracedo

This study shows that loss of UFMylation promotes prostate cancer metastasis by reprogramming glucose metabolism towards hexosamine biosynthesis.

DOI 10.1101/2025.06.02.657324

humanbulk RNA-seq

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Cancer BiologyCell Death and DiseasePeer-reviewedApr 23, 2025

Secreted spermidine synthase reveals a paracrine role for PGC1a-induced growth suppression in prostate cancer

Ariane Schaub-Clerigué, Ivana Heřmanová, Ainara Pintor-Rial…·Verónica Torrano

This study identifies spermidine synthase as a PGC1-regulated secreted protein that mediates paracrine tumor suppression in prostate cancer, highlighting a non-cell autonomous mechanism.

3 citations

humanbulk RNA-seq

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Cell BiologyCell Communication and SignalingPeer-reviewedFeb 19, 2025

Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome

Laura Merino‐Cacho, Orhi Barroso‐Gomila, Mónica Pozo-Rodríguez…·James David Sutherland

The paper demonstrates that BioE3 can identify endogenous substrates and neosubstrates of Cullin-RING ligases, revealing changes in the ubiquitination landscape upon molecular glue treatment.

8 citations

humanproteomics

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Cell BiologyNature CommunicationsPeer-reviewedNov 23, 2023

BioE3 enables the identification of bona fide targets of E3 ligases

Orhi Barroso‐Gomila, Laura Merino‐Cacho, Veronica Muratore…·James David Sutherland

BioE3 identifies substrates of UbL E3 ligases by site-specific biotinylation and proteomic analysis, revealing both known and novel targets for various E3 ligases.

64 citationstop 3%

proteomicsexperimental assay

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