Félix Elortza

The paper identifies ANKRD55 interacting with an IFT-B-like complex in microglia, suggesting a role in ciliary transport independent of ciliogenesis.

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

This study shows that loss of PGC1α in prostate cancer leads to ECM remodeling via CTHRC1, promoting tumor aggressiveness.

This study shows that the stiffness and viscoelasticity of adipose tissue-derived hydrogels affect breast cancer cell proliferation, growth, migration, and invasion.

This study shows astrocytic AMPK links metabolic signals to hypothalamic circadian timing by regulating phosphoproteome organization and behavior.

The paper isolates and characterizes two marine filamentous fungi, analyzing their secondary metabolite production and enzymatic responses to algal polysaccharides.

This study identifies key residues in Siglec-10 involved in ligand recognition and shows that antibody blockade can restore CAR-T cell cytotoxicity.

This study shows that loss of UFMylation promotes prostate cancer metastasis by reprogramming glucose metabolism towards hexosamine biosynthesis.

This study identifies spermidine synthase as a PGC1-regulated secreted protein that mediates paracrine tumor suppression in prostate cancer, highlighting a non-cell autonomous mechanism.

The paper demonstrates that BioE3 can identify endogenous substrates and neosubstrates of Cullin-RING ligases, revealing changes in the ubiquitination landscape upon molecular glue treatment.

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

This study identifies the structural mechanism by which Wnt7a binds to exosomes for secretion, showing it is independent of palmitoylation and involves a dilysine motif interacting with COPB2.

This study investigates the role of VirR in Mycobacterium tuberculosis vesicle production and links it to cell wall remodeling, suggesting potential therapeutic targets.

BioE3 identifies substrates of UbL E3 ligases by site-specific biotinylation and proteomic analysis, revealing both known and novel targets for various E3 ligases.

This study thermodynamically stabilizes human frataxin using computational methods, improving its stability and resistance to proteolysis without compromising function.