Monika C. Wolkers

The paper identifies proteomic regulators of T cell functionality in cancer using proteomic and transcriptomic profiling of tumor-infiltrating T cells.

The paper identifies RNA binding proteins and cis-regulatory elements that control translation in human effector T cells through multi-omics and machine learning analysis.

This study identifies an early mTOR-dependent window during human T cell activation that programs cytotoxic fate or memory-like state, with transient inhibition promoting memory while preserving effector functions.

The paper maps dynamic RNA-binding proteins in human effector T cells and identifies TUT1 and SF3A1 as regulators of differentiation and cytotoxicity.

This study identifies a novel mTOR-dependent mechanism regulating cytokine production in T cells through 3UTR AU-rich elements and DDX21 binding.

This study uses single-molecule FISH to analyze cytokine mRNA dynamics in T cells, revealing transcriptional heterogeneity and post-transcriptional regulation by HuR.

The paper shows that γδ T cells, not β T cells, are the main anti-tumoral immune cells in pediatric neuroblastoma after chemotherapy.

The paper maps the ZFP36L1 interactome in human T cells using proximity labeling, revealing its role in post-transcriptional regulation and protein expression.

SONAR, a machine learning pipeline, learns the sequence code for protein abundance in human immune cells, revealing cell type-specific and activation-dependent sequence features that can enhance T cell receptor expression.

This study shows that deleting both ZFP36L1 and ZFP36L2 in T cells greatly increases cytokine production but reduces cell viability and signaling.

This study identifies that high B cell infiltrates in NSCLC tumors, associated with tertiary lymphoid structures, negatively correlate with the tumor-reactivity of expanded TIL products.

This study shows ZFP36L2 regulates IFNγ production in T cells differently depending on activation context and time, by destabilizing Ifng mRNA in an AU-rich element-dependent manner.

The paper evaluates gene and protein sequence features as predictors of HLA class I ligand presentation, showing they improve predictions comparable to experimental gene expression data.

The paper identifies immature and mature subsets of IFNγ-producing γδ T cells, showing IL-27 supports cytotoxic function in mature cells but not immature ones.

The paper analyzes circRNA expression during hematopoietic differentiation and finds limited evidence for their translation or regulatory role in erythroid and megakaryoid cells.