Siavash K. Kurdistani

This study shows yeast nucleosomes have copper reductase activity regulated by zinc, which affects copper bioavailability and cellular growth.

The paper shows that reducing histone H3-mediated Cu1+ production restores Fe-S cluster deficiencies in yeast, linking chromatin and mitochondrial function to Fe-S cluster homeostasis.

The paper shows the histone H3-H4 tetramer acts as a copper reductase enzyme, reducing Cu2+ to Cu1+ and affecting cellular processes dependent on reduced copper.

The paper shows that amino acid restriction increases translational capacity through H4K20me1 demethylation and c-MYC activation in human cells.

The paper uses Tethered Chromosome Conformation Capture to analyze adenovirus-host genome interactions in human lung fibroblasts, finding specific and non-random interactions enriched in active chromatin regions.