Nicolas Tchitchek

The paper identifies a shared Treg dysfunction signature across rheumatic diseases, suggesting a therapeutic window of opportunity for Treg-targeted treatments.

The paper develops a gene signature to distinguish type 1 diabetic patients from healthy donors using whole blood transcriptomic data, finding that combining multiple analytical methods improves classification accuracy.

This study identifies Treg dysfunction as associated with OA-related pain through multi-omic analysis of peripheral blood from knee OA patients.

AnalyzAIRR provides a user-friendly R package for analyzing bulk AIRR sequencing data, enabling comprehensive immune system analysis through advanced statistical and visualization tools.

This study shows IL-1β signaling affects Tfh and Tfr cells in human lymphoid tissues, linking it to autoantibody production and autoimmune disease.

Maternal immune activation causes Treg deficiency in offspring, leading to brain inflammation and autism-like behaviors, which can be reversed by Treg stimulation.

The paper identifies uterine tissue-resident regulatory T cells (uTregs) that support fetal growth by promoting uterine remodeling and vascular development during pregnancy.

This paper shows that targeting MOG to skin macrophages via a fusion protein prevents EAE in macaques by inducing TGFβ-mediated peripheral tolerance.