Giovanni Bruno Brandani

This paper introduces a physics-based model to simulate chromatin domain dynamics driven by epigenetic factors, revealing that nucleosome-nucleosome interactions shape genomic organization.

This study uses molecular dynamics simulations to show that SMC complexes translocate DNA unidirectionally by capturing DNA segments and pumping them through an asymmetric kleisin path.

The paper investigates multiphase separation in postsynaptic density components, showing that membrane geometry and CaMKII valency and volume drive morphology reversal between solution and membrane environments.

The paper develops a multiscale modeling pipeline to simulate chromatin organization and transcription regulation in mouse embryonic stem cells, revealing how sequence-regulated accessibility facilitates enhancer-promoter communication.

This paper introduces Hi-C metainference, a Bayesian method to model chromatin organization, revealing that gene loci in mouse embryonic stem cells are dynamically condensed and organized as crumpled globules.