Hiam Abdala‐Valencia

This study identifies interstitial macrophages as key drivers of chronic lung allograft dysfunction and suggests CSF1R as a therapeutic target.

The paper investigates the role of maintenance DNA methylation in age-related changes in Treg cell transcriptional and DNA methylation signatures using UHRF1-deficient mice.

This study identifies distinct pneumonia endotypes based on pathogen-specific host responses in the lung, linking them to clinical outcomes and suggesting personalized treatment strategies.

This study identifies and characterizes splenic macrophage subsets in mouse and human, revealing their ontogeny, dynamics, and age-related changes.

This study shows that influenza A infection accelerates the formation of disease-associated microglia in aging mice, with effects observed in white matter regions.

The paper identifies transcriptional and methylation signatures in umbilical cord blood linked to BPD risk in preterm infants.

The paper identifies profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in SSc-ILD by analyzing BAL fluid and lung explants.

This paper introduces RREM-seq, an enzyme-based reduced representation DNA methylation sequencing method that enables high-resolution profiling of low-input samples, including clinical specimens.

This study shows AMPK is necessary for Treg cell adaptation to metabolic stress in tumors and lung injury but not for baseline immune homeostasis.

This study shows that DNA methylation via UHRF1 is essential for iTregs to promote lung recovery after viral pneumonia.

This study identifies tissue-resident skeletal muscle macrophages that support muscle recovery from viral pneumonia in aging mice, with Mertk playing a key role.

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

The paper identifies a systemic age-dependent transcriptome imbalance driven by transcript length across multiple species and shows its correlation with splicing factors and environmental stressors.

Single-cell RNA-seq of lung tissue from transplant donors, fibrosis patients, and a living patient identifies cell type-specific disease-associated molecular pathways in pulmonary fibrosis.