Madhav Jagannathan

The paper shows that protein-driven osmotic pressure regulates nuclear size and function, affecting chromatin organization and gene expression in yeast, human, and fly cells.

This study identifies nuclear stress bodies in Drosophila germline that mediate a stress response by delaying Hsf-dependent transcription and enabling selective expression of molecular chaperones over transposable elements.

This study identifies Brl1 and Brr6 as conserved fusogens mediating membrane fusion during NPC assembly in eukaryotes.

The paper demonstrates that satellite DNA barcodes facilitate meiotic pairing in Drosophila by showing that repeat mismatches disrupt pairing and that pairing defects correlate with oocyte death.

This study identifies CLCC1 as a Torsin1A binding partner essential for nuclear envelope membrane fusion during NPC biogenesis, showing its therapeutic potential for DYT1 dystonia.

This study shows that nuclear mechanostability arises from satellite DNA condensation into chromocenters, which help dissipate mechanical stress and protect genome integrity.

This paper presents a SNP-based crossover map for Drosophila mauritiana, showing reduced centromere suppression of crossing over compared to D. melanogaster.

The paper identifies Stonewall as a protein that positions chromatin at the nuclear periphery in Drosophila, linking this positioning to gene repression and germline stem cell fate.

The paper shows that genome organization influences NPC formation and differentiation in Drosophila oogenesis by regulating gene silencing and Nup activation.

The paper shows that chromocenter formation in Drosophila depends on interactions between satellite DNA-binding proteins D1 and Prod, which package chromosomes into a single nucleus.